Dialectical Behavior Therapy (DBT) is a modified cognitive-behavioral treatment that is the only Evidence-Based Practice to prevent suicide. All findings suggest that DBT is more effective at targeting and reducing suicidal and non-suicidal self-injurious behavior, improving treatment retention, reducing medical lethality of suicide attempts, decreasing hospitalizations and ER visits. It is also effective at reducing therapist burnout and costs associated with treatment of multi-diagnostic clients.